Genomic analyses identify 15 risk loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally occurring canine model of gastric cancer

Proceedings of the National Academy of Sciences, Volume 122, Issue 22, June 2025.
SignificanceGastric cancer is the fifth most common cause of human cancer deaths, but the genetic underpinnings are poorly understood. Harnessing the genetic homogeneity of purebred dogs, we identify 18 loci governing gastric cancer susceptibility in a …
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